Drug intelligence / Profile preview

wrightia tinctoria oil

Development stage
Preclinical
Modality
Small Molecules
Administration
Topical
01

Overview

Wrightia tinctoria oil is a botanical extract derived from the *Wrightia tinctoria* plant, a small deciduous tree commonly known as "Sweet Indrajao" or "Pala indigo." It is a staple in traditional Ayurvedic medicine, particularly for the treatment of psoriasis and other inflammatory skin disorders. The oil contains various phytochemicals, including flavonoids, steroids, and triterpenoids, which provide anti-inflammatory, analgesic, and wound-healing properties. In modern pharmaceutical research, it is being investigated as a synergistic component in advanced topical delivery systems, such as lyotropic liquid crystals and film-forming gels, to improve the solubility and efficacy of hydrophobic drugs like pimecrolimus. Its primary mechanism involves the downregulation of pro-inflammatory cytokines and the modulation of the skin's immune response.

Other names
WTOPala indigo oilSweet Indrajao oil777 oil
02

Targets

IL-17A (Interleukin-17A)TNFA (Tumor necrosis factor alpha (soluble))

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