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WSD0329

Development stage: Preclinical
Lead developer: Wayshine Biopharm
Modality: Small Molecules

Overview

WSD0329 is a blood-brain barrier (BBB) penetrating small molecule inhibitor developed by Wayshine Biopharm, Inc. for the treatment of glioblastoma (GBM), brain cancer, and central nervous system (CNS) metastasis. It functions by inhibiting cancer cell migration through the targeting of the MerTK/p-SRC/p-STAT3/Kras signaling pathway in GBM-like stem cells. By modulating these key signaling nodes, WSD0329 aims to address the invasive nature of glioblastoma and prevent the progression of metastatic brain tumors.

Targets

SRC (Proto-oncogene tyrosine-protein kinase Src)MERTK (MER proto-oncogene, tyrosine kinase)STAT3 (Signal Transducer and Activator of Transcription 3)

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