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**WT** is an orally administered concentrated traditional Chinese medicine powder under clinical evaluation by Changhua Christian Hospital for **spinocerebellar ataxia type 3**. Its composition and individual bioactive constituent were not publicly specified in the registered trial. The trial rationale states that WT contains a principal bioactive constituent reported preclinically to protect against glutamate-induced neurotoxicity, promote neurogenesis, and increase insulin-like growth factor 1 protein expression in ischemic rat brain. WT was studied in a randomized, double-blind, placebo-controlled crossover Phase 2 pilot trial using 3 g twice daily for 12 weeks per treatment period.
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