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WT-1-2.0 is a small molecule antagonist targeting the P2X3 receptor, currently in preclinical development by Hangzhou Westan Pharmaceutical Technology. The P2X3 receptor is a ligand-gated ion channel primarily expressed on sensory neurons and is known to play a critical role in the mediation of chronic pain and cough. By inhibiting P2X3, WT-1-2.0 aims to provide a therapeutic option for various pain conditions. The drug is currently undergoing druggability optimization to refine its pharmacological profile for further clinical advancement.
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