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WT1 cancer vaccine
- Development stage
- Preclinical
- Lead developer
- Shining Biotech
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intradermal, Subcutaneous, Intramuscular
01
Overview
WT1 cancer vaccine is an experimental immunotherapy being developed by Shining Biotech for the treatment of solid tumors. The vaccine targets the Wilms' Tumor 1 (WT1) antigen, a zinc-finger transcription factor that is highly expressed in a variety of cancers but has limited expression in normal adult tissues. By presenting WT1-derived antigens, the vaccine is intended to stimulate a cytotoxic T-lymphocyte (CTL) response specifically against tumor cells that overexpress WT1. As of 2024, the program is in the preclinical stage of development.
- Other names
- WT1 vaccineWT-1 vaccineWT 1 vaccineWilms' Tumor 1 antigen cancer vaccine
02
Targets
pMHC-I (Peptide–MHC class I complex)HLA-A*24 (Major histocompatibility complex class I molecule presenting MAGE-A4 peptide)
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