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WT1 peptide-pulsed dendritic cell vaccine (Shinshu University)
- Development stage
- Unknown
- Lead developer
- Center for Advanced Cell Therapy, Shinshu University Hospital
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
WT1 peptide-pulsed dendritic cell vaccine is an autologous cellular immunotherapy designed to treat cancers overexpressing the Wilms' tumor 1 (WT1) protein. The vaccine is produced by harvesting a patient's peripheral blood mononuclear cells, differentiating them into dendritic cells (DCs), and loading them with WT1-derived peptides. These pulsed DCs are then injected back into the patient, where they present WT1 antigens to the immune system, specifically activating cytotoxic T lymphocytes (CTLs) to recognize and destroy WT1-positive tumor cells. In clinical studies like the PANC-DC/S1 trial in Japan, this vaccine is being evaluated as an adjuvant treatment following curative resection for pancreatic cancer, often in combination with chemotherapy such as S-1, to prevent recurrence and improve survival outcomes.
- Other names
- WT1-pulsed dendritic cell vaccineWT-1-pulsed dendritic cell vaccineWT 1-pulsed dendritic cell vaccineWT1-DC vaccineWT-1-DC vaccineWT 1-DC vaccineWT1-pulsed DC vaccineWT-1-pulsed DC vaccineWT 1-pulsed DC vaccine
02
Targets
WT1-TCR (WT1-specific T-cell receptor)Wilms' tumor 1-derived peptide-human leukocyte antigen class I complexWT1-HLA-II (Wilms tumor protein 1-derived peptide-human leukocyte antigen class II complex)
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