Drug intelligence / Profile preview

wufuyin

Development stage
Preclinical
Lead developer
Shaoxing Hospital of Traditional Chinese Medicine
Administration
Oral
01

Overview

Wufuyin is a traditional Chinese medicine (TCM) herbal formula, originally documented in the Ming Dynasty medical text *Jingyue Quanshu*. It is composed of five primary botanical ingredients: Panax ginseng (Ren Shen), Rehmannia glutinosa (Shu Di Huang), Angelica sinensis (Dang Gui), Atractylodes macrocephala (Bai Zhu), and Glycyrrhiza uralensis (Zhi Gan Cao). Traditionally used to tonify the kidney, nourish the blood, and strengthen the spleen, Wufuyin has been investigated in modern clinical research for its potential therapeutic effects on discogenic back pain. Studies conducted by the Shaoxing Hospital of TCM have focused on its ability to modulate the Wnt/β-catenin signaling pathway, as indicated by changes in serum β-catenin levels. This pathway is a critical regulator of intervertebral disc cell metabolism, and its modulation may help mitigate the degenerative processes associated with discogenic pain.

Brand names
Wufuyin
Other names
Wu Fu Yin五福饮
02

Targets

MAPK14 (p38 mitogen-activated protein kinase alpha)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)GSK3 (Glycogen synthase kinase 3 beta)NOS2 (Nitric Oxide Synthase 2)CDK2 (Cyclin-dependent kinase 2)PPARG (Peroxisome proliferator-activated receptor gamma)

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