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Wujia Yizhi Granules
- Development stage
- Phase 3
- Lead developer
- Sichuan Jishengtang Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Wujia Yizhi Granules is a Traditional Chinese Medicine (TCM) formulation developed by Sichuan Jishengtang Pharmaceutical Co., Ltd. for the treatment of mild to moderate Alzheimer's disease. The product is a botanical extract-based therapy, likely incorporating ingredients such as *Acanthopanax* (Wujia) and *Alpinia oxyphylla* (Yizhi), which are traditionally associated with cognitive enhancement and neuroprotection in Chinese medicine. It is currently undergoing clinical evaluation in China to determine its safety and therapeutic efficacy in improving cognitive symptoms in patients with dementia, specifically targeting the TCM syndrome of deficiency of kidney essence and marrow.
- Brand names
- Wujia Yizhi Granules
- Other names
- 五加益智颗粒
02
Targets
AcetylcholinesteraseBACE1 (Beta-site APP-cleaving enzyme 1)Aβ (Amyloid-beta peptides and aggregates)Janus kinase 2/Signal transducer and activator of transcription 3 signaling pathway in astrocytes
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