Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
wulingshen
- Development stage
- Phase 4
- Lead developer
- Zhejiang Jolly Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Wulingshen (Xylaria nigripes) is a medicinal fungus used in Traditional Chinese Medicine (TCM), primarily developed and marketed by Zhejiang Jolly Pharmaceutical as Wuling Capsule (乌灵胶囊). It is produced through the fermentation of the mycelia of Xylaria nigripes. The drug is indicated for the treatment of insomnia, anxiety, and depression, and is being investigated for conditions such as post-stroke fatigue and comorbid depression in patients with epilepsy. Its mechanism of action is primarily linked to the modulation of the GABAergic and glutamatergic systems; it has been shown to increase the levels of gamma-aminobutyric acid (GABA) and the activity of glutamate decarboxylase (GAD) while reducing glutamate levels in the brain, thereby exerting sedative and anxiolytic effects.
- Brand names
- Wuling Capsule乌灵胶囊
- Other names
- Xylaria nigripesWuling乌灵参
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)GABA-B (Gamma-aminobutyric acid receptor type B)
Beyond the preview
Go deeper on wulingshen.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on wulingshen.