Drug intelligence / Profile preview

Wushen

Development stage
Preclinical
Administration
Oral
01

Overview

Wushen refers to a group of traditional Chinese medicine preparations, including an oral liquid, a decoction, and a food mixture. The food mixture is described as containing 55 different natural ingredients. It has demonstrated anti-aging effects by modulating gut microbiota and metabolites. Wushen also exhibits antitumor activity, particularly against S180 tumor growth in vivo, partly due to its antioxidant properties. As a traditional Chinese medicine, Wushen Decoction has been historically used to treat lower extremity erysipelas, with its mechanism involving the modulation of the TNF and NF-kappa B signaling pathways. An herbal formula of Wushen has also shown effectiveness in treating postinfarction heart failure by improving cardiac function, reducing arrhythmia susceptibility, and mitigating adverse cardiac remodeling through the inhibition of TGFβ1/SMADs-mediated extracellular matrix deposition and Rac1/NOX2/CTGF/Connexin43-involved gap junction remodeling.

Other names
五参口服液Wushen Oral LiquidWushen DecoctionHerbal formula WuShen
02

Targets

CTGF (Connective tissue growth factor)GJA1 (Connexin43 Hemichannel)NFKB1 (NF-κB1)NOX2 (NADPH oxidase 2)RAC1 (Rac family small GTPase 1)SMAD (SMAD family)TGFB1 (Transforming growth factor Beta-1 proprotein)NF-κBPTGS2 (Prostaglandin-Endoperoxide Synthase 2)TNFA (Tumor necrosis factor alpha (soluble))

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