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Wuwei Fuzheng Yijing Decoction

Development stage: Unknown
Lead developer: First Affiliated Hospital of Henan University of Chinese Medicine
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Wuwei Fuzheng Yijing Decoction is a Traditional Chinese Medicine (TCM) herbal formula developed by The First Affiliated Hospital of He'nan University of Chinese Medicine for the treatment of male infertility. The decoction is formulated based on TCM principles to "strengthen the body's resistance" (Fuzheng) and "benefit the essence" (Yijing), targeting improvements in semen quality and sperm DNA integrity. Clinical research, including a randomized controlled trial (ChiCTR2200063340), has investigated its efficacy in improving sperm quality parameters and reducing the sperm DNA fragmentation index (DFI). A unique focus of recent study involves evaluating the decoction's potential to mitigate the presence and impact of environmental microplastics in human semen, comparing its performance against standard antioxidant treatments like Vitamin E and Coenzyme Q10.

Other names: Wuwei Fuzheng Yijing Tang五味扶正益精汤

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