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Wuwei Ganlu Medicinal Bath Granules

Development stage
Preclinical
Modality
Small Molecules
Administration
Topical
01

Overview

Wuwei Ganlu Medicinal Bath Granules (WGMG) is a standardized Tibetan herbal preparation derived from the traditional 'Five-Flavored Nectar' decoction, a cornerstone of Lum medicinal bathing in Sowa Rigpa (Tibetan medicine). The formulation is based on the *Four-Tantras* (rGyud-bzhi), a classic Tibetan medical text dating from the 8th to 12th centuries. It is composed of equal proportions of five medicinal plants: *Juniperus formosana* (branch and leaf), *Rhododendron anthopogonoides* (flower), *Myricaria germanica* (stem and leaf), *Ephedra saxatilis* (stem), and *Artemisia sieversiana* (whole plant). WGMG is primarily indicated for the treatment of rheumatoid arthritis (RA), where it exerts anti-inflammatory effects by blocking the Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) and NOD-like receptor pyrin domain-containing 3 (NLRP3) signaling pathways. The bioactive compounds are absorbed through the skin during the medicinal bathing process to alleviate joint inflammation and pain.

Brand names
Wuwei Ganlu Medicinal Bath Granules五味甘露药浴颗粒
Other names
Wuwei GanluFive-Flavored NectarFive-Flavored Nectar Medicinal Bath GranulesWuwei Ganlu Decoction
02

Targets

IKKα/β (Inhibitor of nuclear factor kappa-B kinase subunit alpha and beta)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)MYD88 (Myeloid differentiation primary response protein MyD88)TLR4 (Toll-like receptor 4)

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