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Wuwei Kushen
- Development stage
- Phase 2
- Lead developer
- Beijing Zhonghui Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Wuwei Kushen is a Traditional Chinese Medicine (TCM) formulation developed by Beijing Zhonghui Pharmaceutical for the treatment of ulcerative colitis. It is typically administered as enteric-coated capsules to ensure targeted delivery to the intestinal tract. The formulation is composed of five primary herbal ingredients: *Sophora flavescens* (Kushen), *Sanguisorba officinalis* (Di Yu), *Indigo naturalis* (Qing Dai), *Bletilla striata* (Bai Ji), and *Glycyrrhiza uralensis* (Gan Cao). Its mechanism of action involves multi-target anti-inflammatory and immunomodulatory effects, including the inhibition of pro-inflammatory cytokines such as TNF-alpha, IL-6, and IL-1 beta, as well as the regulation of the NF-kappaB signaling pathway. Additionally, it promotes the healing of the intestinal mucosa and helps restore the balance of intestinal flora. It is specifically indicated for patients presenting with the damp-heat syndrome of the large intestine in TCM clinical practice.
- Brand names
- Wuwei Kushen
- Other names
- Wuwei Kushen Enteric-coated CapsulesWuwei Kushen Changrong Jiaonang
02
Targets
CYP2B6 (Cytochrome P450 2B6)CYP2C19 (Cytochrome P450 2C19)CYP2C8 (Cytochrome P450 2C8)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)CYP3A4 (Cytochrome P450 3A4)ER (Estrogen receptor)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)STAT3 (Signal Transducer and Activator of Transcription 3)TYR (Tyrosinase)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)NF-κBTNFA (Tumor necrosis factor alpha (soluble))
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