Drug intelligence / Profile preview

wuzhi jiaonang

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Wuzhi Jiaonang (Wuzhi capsule) is a traditional Chinese medicine preparation made from an ethanol extract of the fruit of Schisandra sphenanthera (Nan-Wuweizi). Its main active ingredients include schisandrin, schizandrol B, schisantherin A, schisanhenol, and deoxyschizandrin. The formulation is primarily used in China for liver protection and as an adjunct therapy in organ transplant recipients to treat drug-induced hepatitis. It is known to significantly increase the blood concentration of tacrolimus when coadministered by inhibiting its metabolism—an effect that should be considered due to potential herb-drug interactions[1][2]. The product has been registered for use in China.

Brand names
Wuzhi JiaonangWuzhi capsuleWZC
Other names
Wuzhi capsuleWZC
02

Targets

NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)CYP3A4 (Cytochrome P450 3A4)CYP2E1NF-κB

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