Drug intelligence / Profile preview

wuzi yanzong wan

Development stage
Unknown
Lead developer
Ganzhou Hospital of Traditional Chinese Medicine
Administration
Oral, Topical
01

Overview

Wuzi Yanzong Wan is a classical Traditional Chinese Medicine (TCM) herbal formula, often referred to as the "Five Seed Formula." It is composed of five botanical ingredients: *Lycium barbarum* (Goji berry), *Cuscuta chinensis* (Dodder seed), *Rubus chingii* (Chinese raspberry), *Schisandra chinensis* (Five-flavor berry), and *Plantago asiatica* (Plantago seed). In TCM, it is used to tonify the kidneys and replenish vital essence (Jing), with primary indications including male infertility, oligospermia, asthenospermia, premature ejaculation, and erectile dysfunction. Pharmacological studies indicate that the formula may act through the P38 MAPK-ADAM17 signaling pathway to regulate apoptosis during spermatogenesis and influence amino acid and lipid metabolism. While traditionally administered as oral honey-bound pills, specialized variations such as the "Wuzi ironing formula" are being investigated for topical application in musculoskeletal conditions like shoulder periarthritis.

Brand names
FertifruitsWu Zi Yan Zong Pian
Other names
Wu Zi Yan Zong WanFive Ancestors TeapillsFive Seed Derivative PillsWuzi ironing formula
02

Targets

TAp73 (Tumor protein p73)KIT (c-KIT proto-oncogene receptor tyrosine kinase)ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)ADAM17 (A disintegrin and metalloprotease 17)RK (Ribokinase)MAPK3 (Mitogen-activated protein kinase 1)JNK (Mitogen-activated protein kinase kinase kinase family)

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