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WZS0347
- Development stage
- Preclinical
- Lead developer
- Chinese Academy of Sciences
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules
01
Overview
WZS0347: sourced facts only. name: "In this study, we present the discovery of WZS0347, a first-in-class proteolysis targeting chimera (PROTAC) designed to target MITF for degradation." [PMID:41259997]; target: "In this study, we present the discovery of WZS0347, a first-in-class proteolysis targeting chimera (PROTAC) designed to target MITF for degradation." [PMID:41259997]; developer: "State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Rd., Shanghai, 200032, China; University of Chinese Academy of Sciences, #1 Yanxihu Road, Huairou District, Beijing, 101408, China." [PMID:41259997]; modality: "In this study, we present the discovery of WZS0347, a first-in-class proteolysis targeting chimera (PROTAC) designed to target MITF for degradation." [PMID:41259997]; stage: "WZS0347 potently reduced MITF protein levels in several melanoma cell lines, including B16F10, A375 and GAK." [PMID:41259997]
02
Targets
MITF (Melanocyte inducing transcription factor)
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