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XA-4
- Development stage
- Preclinical
- Lead developer
- Xaira Therapeutics
- Modality
- Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes, Peptides
- Administration
- Intravenous, Subcutaneous
01
Overview
XA-4 refers to two distinct preclinical drug candidates. The first is a de novo designed single-domain antibody (VHH) developed by Xaira Therapeutics using its X-Design generative AI platform. It targets an undisclosed, complex G-protein coupled receptor (GPCR) that has historically been intractable to conventional antibody discovery methods. It is currently in lead optimization for immunology and inflammatory diseases. The second is a recombinant peptide-XTEN conjugate developed by researchers at Zunyi Medical University. It is a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist based on the AWRK6 peptide, designed for the treatment of type 2 diabetes mellitus and, in combination with double shRNA, herpes simplex virus type 2 (HSV-2) infection.
02
Targets
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