xanthoangelol

Xanthoangelol is a bioactive chalcone primarily isolated from the Ashitaba plant (*Angelica keiskei*). It has been extensively studied for its diverse pharmacological properties, including anti-tumor, anti-inflammatory, and anti-diabetic activities. In the context of oncology, xanthoangelol acts as a dual inhibitor of the BRAF and PI3-K signaling pathways, which are frequently dysregulated in various cancers, particularly melanoma. By targeting these kinases, xanthoangelol suppresses downstream signaling, leading to G1 phase cell cycle arrest and the induction of apoptosis. Preclinical research has demonstrated that xanthoangelol can significantly reduce tumor incidence and volume in BRAF-activated and Pten-deficient melanoma models, suggesting its potential as a chemopreventive or therapeutic agent.

Other names

xanthoangelol A