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XEN-101 is an orally administered, gut-restricted small molecule being developed by Xeno Biosciences for the treatment of obesity and metabolic diseases. The drug is designed to mimic the physiological and metabolic benefits of Roux-en-Y Gastric Bypass (RYGB) surgery, which is considered a highly effective surgical intervention for weight loss. XEN-101 works by modulating the gut environment and microbiome to induce a metabolic state similar to that achieved post-surgery, potentially offering a non-invasive alternative to bariatric procedures. As of early 2024, XEN-101 is in Phase 1b clinical development to evaluate its safety, tolerability, and pharmacodynamic effects in individuals with obesity.
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