Xen2174

Xen2174 is a synthetic 13-amino acid peptide derived from the venom of the marine cone snail *Conus marmoreus*. It belongs to a novel class of molecules known as chi conopeptides. Xen2174 acts as a highly selective inhibitor of the norepinephrine transporter (NET), blocking norepinephrine reuptake in the central nervous system and thereby increasing norepinephrine levels. This mechanism activates inhibitory pain pathways and prevents pain signals from reaching the brain. Xen2174 was developed for intrathecal administration to treat moderate to severe pain, including chronic cancer pain and postoperative pain. Preclinical studies demonstrated potent antinociceptive effects superior in duration and magnitude to morphine in animal models[1][2][3][5][8].

Other names

chi conopeptide analoguesynthetic conopeptide peptide