Xenadrine EFX

Xenadrine EFX is a multi-ingredient dietary supplement marketed for weight loss and energy enhancement. It was developed as an "ephedra-free" (EFX) alternative following the FDA ban on ephedrine alkaloids in dietary supplements. The formulation typically contains a blend of stimulants, including caffeine, guarana extract, and bitter orange (*Citrus aurantium*) extract standardized for synephrine. Synephrine acts as a sympathomimetic agent, primarily targeting alpha-adrenergic receptors, which can increase systemic vascular resistance and blood pressure. Clinical studies and case reports have associated its use with cardiovascular stimulant effects, including hypertensive urgency and increased heart rate, particularly when combined with caffeine.

Brand names

Xenadrine EFX

Other names

Xenadrine