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XG004

Development stage: Unknown
Lead developer: Xgene Pharmaceutical Group
Modality: Small Molecules
Administration: Topical

Overview

XG004 is an investigational **topical gel** containing a single small-molecule naproxen-pregabalin prodrug conjugate developed by Xgene Pharmaceutical Group for painful osteoarthritis of the knee. Following dermal absorption and enzymatic cleavage, it is designed to deliver naproxen-mediated cyclooxygenase inhibition and pregabalin-mediated modulation of voltage-dependent calcium-channel alpha-2/delta subunits, addressing inflammatory nociceptive pain and neuropathic pain components. In a completed randomized placebo-controlled Phase 1b/2a knee-osteoarthritis study, XG004 topical gel showed acceptable tolerability and exploratory improvements in pain, physical function, and sleep-related outcomes. ([xgenepharm.com](https://www.xgenepharm.com/wp-content/uploads/2023/05/PDF.pdf))

Other names: naproxen/pregabalin conjugate

Targets

CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)CACNA2D2 (α2δ-2)PGHS-1 (Prostaglandin G/H Synthase 1)

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