Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
XHANCE (OptiNose)
- Development stage
- Approved
- Lead developer
- OptiNose
- Modality
- Small Molecules
- Administration
- Intranasal
01
Overview
XHANCE (OPN-375) is a drug-device combination product developed by Optinose for the treatment of chronic rhinosinusitis with or without nasal polyps. It consists of the topical corticosteroid fluticasone propionate delivered via a proprietary Exhalation Delivery System (EDS). The EDS technology is breath-powered, using the patient's own exhaled breath to naturally close the soft palate and deliver the medication high and deep into the nasal cavity, specifically targeting the ostiomeatal complex and paranasal sinuses where inflammation is most prevalent. Fluticasone propionate acts as a potent agonist of the glucocorticoid receptor, exerting anti-inflammatory effects that reduce mucosal swelling and improve sinus drainage. It was the first drug-device combination to receive FDA approval for the treatment of chronic rhinosinusitis without nasal polyps.
- Brand names
- XHANCE
- Other names
- fluticasone propionate exhalation delivery systemfluticasone propionate EDS
02
Targets
GR (Glucocorticoid receptor)
Beyond the preview
Go deeper on XHANCE (OptiNose).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on XHANCE (OptiNose).