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xiangfu siwu formula
- Development stage
- Preclinical
- Lead developer
- Nanjing University of Chinese Medicine
- Administration
- Oral
01
Overview
Xiangfu Siwu formula is a traditional Chinese medicine (TCM) herbal decoction derived from the classic Siwu Tang (Four-Substance Decoction). It typically consists of *Cyperus rotundus* (Xiangfu) combined with the four base ingredients of Siwu Tang: *Rehmannia glutinosa*, *Angelica sinensis*, *Paeonia lactiflora*, and *Ligusticum chuanxiong*. Developed and studied by institutions such as the Nanjing University of Chinese Medicine, it is primarily used to treat primary dysmenorrhea. The formula is thought to work by regulating qi and nourishing blood, which translates in modern pharmacological terms to potential anti-inflammatory, analgesic, and antispasmodic effects on the uterine smooth muscle. It has been the subject of metabolomics studies to evaluate its intervention effects in patients with menstrual disorders.
- Other names
- Xiangfu Siwu TangCyperus and Four-Substance DecoctionXiang Fu Si Wu Tang
02
Targets
NOS1 (nNOS)CaV (Voltage-gated calcium channel protein complex)
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