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Xianglei Tangzugu Ointment

Development stage: Preclinical
Lead developer: Foshan Hospital of Traditional Chinese Medicine
Modality: Small Molecules
Administration: Topical

Overview

Xianglei Tangzugu Ointment is a Traditional Chinese Medicine (TCM) formulation applied topically for the treatment of diabetic foot ulcers. Its proposed mechanism of action involves modulating the TREM2-MAPL/AP-1/LIF signaling pathway. Specifically, it is thought to influence Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) to regulate macrophage-related immune responses, suppress inflammation by inactivating MAPK/AP-1 signaling, and promote wound healing through the upregulation of leukemia inhibitory factor (LIF) and stimulation of angiogenesis via the Akt/mTOR/HIF-1α pathway.

Other names: Xianglei Tangzugu

Targets

TREM2 (Triggering receptor expressed on myeloid cells 2)

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