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xiangpi shengji gao
- Development stage
- Preclinical
- Lead developer
- The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Xiangpi Shengji Gao (XPSJG) is a Traditional Chinese Medicine (TCM) topical hospital preparation, typically formulated as an ointment or gel, used to promote tissue regeneration and wound healing. It is primarily indicated for chronic non-healing wounds, pressure ulcers (bedsores), anal fistula wounds, and deep second-degree burns. The formulation modulates several signaling pathways, including the NF-κB/HIF-1α/VEGF and PI3K/AKT/HIF-1α axes, to promote macrophage M1 polarization, stimulate fibroblast proliferation and migration, and upregulate the expression of vascular endothelial growth factor (VEGF), collagen type I alpha 1 (COL1A1), and alpha-smooth muscle actin (α-SMA). It is a multi-component herbal preparation frequently used in clinical settings in China, notably at the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine.
- Other names
- Xiangpi Shengji OintmentXiangpi Shengji GelRubber Shengji Paste
02
Targets
NF-κBACTA2 (Alpha-smooth muscle actin)VEGFA (Vascular endothelial growth factor A)COL1A1 (Collagen type I alpha 1 chain)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)HIF1A (Hypoxia-inducible factor 1-alpha)
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