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xiao ke wan
- Development stage
- Unknown
- Lead developer
- Guangzhou Zhong Yi Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Xiao Ke Wan is a traditional Chinese medicine (TCM) formula used primarily for the management of type 2 diabetes mellitus and its associated symptoms. The name "Xiao Ke" refers to "wasting and thirsting," classic symptoms of diabetes in TCM. The formulation typically contains a combination of various herbs selected for their potential effects on regulating blood sugar levels, improving insulin sensitivity, and alleviating diabetic symptoms such as excessive thirst, frequent urination, and fatigue. Some commercial formulations also include glibenclamide (a sulfonylurea antidiabetic drug) alongside herbal ingredients[1][5]. According to TCM principles, Xiao Ke Wan works by tonifying the spleen and kidney, nourishing yin, clearing heat, generating fluids to stop thirst, and rebalancing the body's energy involved in glucose metabolism[4][5]. It is especially effective for mild or moderate cases where pancreatic function remains partially intact[5].
- Brand names
- Xiao Ke WanXiao Ke PillsDiabetes PillsSpecific Texiao Xiaoke Wan
- Other names
- 消渴丸
02
Targets
SUR1 (Sulfonylurea receptor 1)IRS1 (Insulin receptor substrate 1)AKT (RAC-alpha serine/threonine-protein kinase)TNFA (Tumor necrosis factor alpha (soluble))PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
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