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xiao yao san
- Development stage
- Phase 4
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Oral
01
Overview
Xiao Yao San is a traditional Chinese medicine (TCM) herbal formula composed of eight herbs: Bupleuri radix (Chai Hu), Angelicae radix (Dang Gui or Dong Quai), Paeoniae radix alba (Bai Shao), Atractylodis rhizome macrocephalae (Bai Zhu), Poria cocos (Fu Ling), Zingiberis siccatum rhizome (Sheng Jiang), Menthae haplocalycis (Bo He), and Glycyrrhizae radix (Gan Cao or Licorice)[1][6]. It has been used since the Song Dynasty for the treatment of depression, anxiety, stress-related disorders[1][3][4], as well as functional gastrointestinal disorders and polycystic ovary syndrome[1]. The formula is believed to harmonize liver qi stagnation with spleen qi deficiency according to TCM theory. Modern studies suggest it may modulate neurotransmitter systems involved in mood regulation and influence metabolic pathways related to glutamate metabolism[4]. Modified forms such as Jia Wei Xiao Yao San add additional herbs for broader indications.
- Brand names
- Free and Easy WandererRambling PowderJia Wei Xiao Yao SanDan Zhi Xiao Yao SanAugmented rambling powderKamishoyosanTJ-24TJ24TJ 24
- Other names
- XYSFree and Easy Wanderer's PowderBupleurum and Tang-kuei Formula
02
Targets
ER (Estrogen receptor)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)OCT1 (Organic cation transporter 1)OCT3 (Organic cation transporter 3)TLR4 (Toll-like receptor 4)NTRK2 (Tropomyosin-related kinase receptor type B)
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