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Xiaobi Fang is a Traditional Chinese Medicine (TCM) herbal formula primarily utilized for the treatment of 'Bi syndrome,' a category in TCM that encompasses inflammatory and painful joint conditions such as rheumatoid arthritis, osteoarthritis, and gouty arthritis. The formula is designed to clear heat, resolve dampness, and expel wind-dampness to alleviate joint swelling, pain, and stiffness. While specific herbal compositions can vary by institution or practitioner, common versions often include a core set of herbs such as *Coix lacryma-jobi* (Yi Yi Ren), *Phellodendron amurense* (Huang Bai), *Atractylodes lancea* (Cang Zhu), and *Achyranthes bidentata* (Niu Xi). Pharmacological studies indicate that Xiaobi Fang exerts its therapeutic effects through anti-inflammatory and immunomodulatory mechanisms, specifically by inhibiting the production of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, and by suppressing the TLR4/NF-κB signaling pathway.
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