Drug intelligence / Profile preview

Xiaochaihu Keli

Development stage
Unknown
Lead developer
Huabao Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Xiaochaihu Keli is a traditional Chinese medicine (TCM) herbal formulation in granule form, developed and marketed by Huabao Pharmaceutical. It is based on the classical 'Xiao Chai Hu Tang' (Minor Bupleurum Decoction) formula, which dates back to the Shanghan Lun. The formulation consists of seven primary herbal ingredients: *Bupleurum chinense* (chaihu), *Scutellaria baicalensis* (huangqin), *Pinellia ternata* (banxia), *Codonopsis pilosula* (dangshen), *Glycyrrhiza uralensis* (gancao), *Zingiber officinale* (shengjiang), and *Ziziphus jujuba* (dazao). In TCM practice, it is indicated for harmonizing the Shao Yang stage, typically presenting as alternating chills and fever, chest discomfort, bitterness in the mouth, and nausea. As a complex herbal product, its therapeutic effects are attributed to the synergistic action of various phytochemicals rather than a single molecular target.

Brand names
Xiaochaihu Keli
Other names
小柴胡颗粒Xiao Chai Hu Tang GranulesMinor Bupleurum Granules
02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)IL-6 (Interleukin 6)ESR1 (ERα)EGFR T790M (Epidermal growth factor receptor T790M mutant)MAPK3 (Mitogen-activated protein kinase 1)

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