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Xiaoer Chaige Tuire
- Development stage
- Unknown
- Lead developer
- Suzhou Youseen New Drug R&D
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Xiaoer Chaige Tuire is a pediatric Traditional Chinese Medicine (TCM) formulation developed by Suzhou Yusen New Drug Development Co., Ltd. for the treatment of fever associated with acute upper respiratory tract infections and the common cold. The drug is typically formulated as granules and is based on the traditional "Chaige" herbal pairing, which primarily features *Radix Bupleuri* (Chai Hu) and *Radix Puerariae* (Ge Gen). These components are recognized for their antipyretic, anti-inflammatory, and analgesic properties. The mechanism of action involves the inhibition of inflammatory mediators, specifically reducing the levels of prostaglandin E2 (PGE2) in the hypothalamus and modulating cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), thereby effectively lowering body temperature in children.
- Other names
- Xiaoer Chaige Tuire Granules小儿柴葛退热颗粒
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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