Drug intelligence / Profile preview

Xiaoer Chaigui antipyretic granules

Development stage
Unknown
Lead developer
Guizhou Bailing Group Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Xiaoer Chaigui antipyretic granules (also known as Xiaoer Chaigui Tuire Keli) is a traditional Chinese patent medicine (TCPM) widely used in pediatrics for the treatment of fever, upper respiratory tract infections, influenza, and common colds. The formulation is derived from the classic prescriptions 'Guizhi Gegen Tang' and 'Xiaochaihu Tang' from the Treatise on Cold Damage (Shanghan Lun). It consists of seven herbal ingredients: Bupleurum root (Chaihu), Cassia twig (Guizhi), Kudzuvine root (Gegen), Common ducksmeat herb (Fuping), Scutellariae Radix (Huangqin), White Peony Root (Baishao), and Cicada Slough (Chantui). It functions to promote sweating, release the exterior, clear the interior, and reduce fever. During the COVID-19 pandemic, it was evaluated in clinical trials and recommended in guidelines for the management of pediatric COVID-19.

Brand names
SunflowerXiaokuihua
Other names
Xiao'er Chaigui Tuire GranulesXiao'er Chaigui Tuire KeliXiaoer Chaigui Tuire GranuleXiaoer Chaigui Tuire granulesXiaoer Chaigui Tuire Keli
02

Targets

PI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ESR1 (ERα)EGFR T790M (Epidermal growth factor receptor T790M mutant)

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