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Xiaoer Qingfei Heji
- Development stage
- Preclinical
- Lead developer
- Liaoning University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Xiaoer Qingfei Heji is a traditional Chinese medicine (TCM) herbal formulation developed primarily for pediatric use. It is designed to "clear the lung" and relieve symptoms associated with respiratory tract infections in children, such as cough, fever, and phlegm. The formula is used especially for conditions like pediatric pneumonia and pyretic pulmonary syndrome (PPS). Mechanistically, it acts by modulating inflammatory cytokines (such as TNF-α, IL-1β), neurotransmitters (5-HT, SP, VIP), and gut microbiota composition. Animal studies suggest it reduces lung inflammation and improves intestinal function by decreasing AQP3 expression in colon tissue[2]. Its clinical application focuses on integrative treatment of pediatric pneumonia within TCM practice[1][2].
- Brand names
- Xiaoer Qingfei Heji
- Other names
- 小儿清肺合剂Xiao'er Qingfei MixtureXiao Er Qing Fei He Ji
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))mPGES-2 (Microsomal prostaglandin E synthase-2)VPAC (VIP receptor family)AQP3 (Aquaporin-3 channel protein)IL1B (Interleukin-1 beta)TACR1 (Neurokinin‑1 Receptor)5-HT (Serotonin receptors)
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