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Xiaoke formula
- Development stage
- Unknown
- Lead developer
- Yueyang Hospital of Integrated Traditional Chinese and Western Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Xiaoke formula is a Traditional Chinese Medicine (TCM) herbal preparation investigated for the treatment of refractory type 2 diabetes mellitus, particularly in patients exhibiting the deficiency of Qi and Yin syndrome. The formula is designed to target Protein-tyrosine phosphatase 1B (PTP1B), a key negative regulator of the insulin signaling pathway. By inhibiting PTP1B, Xiaoke formula aims to enhance insulin sensitivity and improve glycemic control. It is typically evaluated as an adjunct to conventional therapies such as metformin and insulin. The development is led by Yueyang Hospital of Integrated Traditional Chinese and Western Medicine and the Shanghai University of Traditional Chinese Medicine.
- Other names
- Xiaoke FangXiaoke decoction
02
Targets
JUN (Transcription factor Jun)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)NOS3 (eNOS)PTPN1 (Protein tyrosine phosphatase 1B)HRAS (H-Ras protein)FGF2
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