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Xiaoketang

Development stage: Unknown
Lead developer: Shanghai Municipal Hospital of Traditional Chinese Medicine
Administration: Oral

Overview

Xiaoketang is a Traditional Chinese Medicine (TCM) formula traditionally used to treat "Xiao Ke" (wasting-thirst syndrome), which corresponds to diabetes mellitus in modern medicine. In clinical research conducted by the Shanghai Traditional Chinese Medicine Hospital, Xiaoketang is being investigated for its potential therapeutic benefits in patients with diabetic nephropathy, often as an adjunctive therapy to standard treatments like valsartan. The mechanism of action is hypothesized to involve the protection of renal podocytes by modulating the expression of key structural proteins such as Nephrin and Podocin. Additionally, Xiaoketang is studied for its ability to inhibit histone deacetylase (HDAC) activity, which may contribute to the reduction of proteinuria and the preservation of renal function in diabetic patients.

Other names: Xiaoke Tang消渴汤

Targets

HDAC (HDAC family)

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