Drug intelligence / Profile preview

Xiaoyao Granules

Development stage
Unknown
Lead developer
Zhejiang Tianyitang Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Xiaoyao Granules is a traditional Chinese medicine (TCM) manufactured by Zhejiang Tianyitang Pharmaceutical, based on the classic "Xiaoyao San" formula. It is an oral herbal formulation primarily indicated for the treatment of liver qi stagnation, which manifests clinically as mood disorders (including depression and anxiety), psychosomatic complaints, and various gynecological symptoms such as irregular menstruation and breast distension. The preparation typically consists of eight botanical ingredients: *Radix Bupleuri* (Chaihu), *Radix Angelicae Sinensis* (Danggui), *Radix Paeoniae Alba* (Baishao), *Rhizoma Atractylodis Macrocephalae* (Baizhu), *Poria* (Fuling), *Radix Glycyrrhizae* (Gancao), *Herba Menthae* (Bohe), and *Rhizoma Zingiberis Recens* (Shengjiang). Pharmacologically, it is thought to exert therapeutic effects by regulating the neuroendocrine-immune system and modulating neurotransmitter levels, although it functions as a multi-target mixture rather than through a single molecular mechanism.

Brand names
Xiaoyao Keli
Other names
逍遥颗粒Xiaoyao Keli
02

Targets

IL1B (Interleukin-1 beta)KEAP1 (Kelch-like ECH-associated protein 1)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NTRK2 (Tropomyosin-related kinase receptor type B)PIK3CA (Phosphoinositide 3-kinase alpha)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)

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