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Xiaoyao Jieyu
- Development stage
- Phase 4
- Lead developer
- Cangzhou Hospital of integrated Traditional Chinese and Western Medicine of Hebei Province
- Administration
- Oral
01
Overview
Xiaoyao Jieyu is a Traditional Chinese Medicine (TCM) formula developed by the Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine for the treatment of post-stroke depression (PSD). The formula is designed based on traditional principles of soothing the liver, strengthening the spleen, and relieving qi stagnation to address the psychological and physiological symptoms following a stroke. Clinical research, including trials registered in the Chinese Clinical Trial Registry (ChiCTR), has investigated its efficacy in improving Hamilton Depression Rating Scale (HAMD) scores and its regulatory effects on serum cytokine levels, which are often elevated in patients with depression. It is typically administered orally as a decoction or liquid preparation.
- Brand names
- xiaoyao jieyu
- Other names
- Xiaoyao Jieyu decoctionXiaoyao Jieyu formula
02
Targets
BDNF (Brain-derived neurotrophic factor)SERT (Sodium-dependent serotonin transporter)MAPK14 (p38 mitogen-activated protein kinase alpha)MAPK3 (Mitogen-activated protein kinase 1)MYC (MYC proto-oncogene protein)JUN (Transcription factor Jun)
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