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Xiaoyu Xiezhuo Decoction
- Development stage
- Unknown
- Lead developer
- The First Affiliated Hospital of Zhejiang Chinese Medical University
- Administration
- Oral
01
Overview
Xiaoyu Xiezhuo Decoction is a Traditional Chinese Medicine (TCM) herbal formulation developed by The First Affiliated Hospital of Zhejiang Chinese Medical University. It is primarily investigated for the treatment of chronic cyclosporine nephropathy, a common renal complication in patients with aplastic anemia undergoing long-term immunosuppressive therapy with cyclosporine. The decoction is hypothesized to exert nephroprotective effects by modulating renal autophagy and activating the ACE2-Ang(1-7)-Mas axis. By influencing these pathways, the treatment aims to mitigate the profibrotic and vasoconstrictive damage typically associated with chronic cyclosporine toxicity, thereby improving renal function and patient outcomes.
- Other names
- Xiaoyu Xiezhuo Yin
02
Targets
ACE2 (Angiotensin-converting enzyme 2)MMP9 (Matrix metalloproteinase-9)Autophagy (Autophagy machinery (ATG family))MAS1 (Mas receptor)TLR4 (Toll-like receptor 4)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)MR (Mineralocorticoid receptor)
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