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XiaoZhongSan is a traditional Chinese medicine (TCM) formula used primarily in China for the treatment of conditions such as knee synovitis and postpartum spleen-qi deficiency. It has been utilized for over 40 years at Ruijin Hospital Affiliated to School of Medicine of Shanghai Jiaotong University[4]. The formulation known as "Baizhu Xiaozhong San" or "compound cottonrose hibiscus leaf ointment/gel plaster" is applied topically and has been studied using metabolomics and microbiome analysis to reveal its endogenous mechanisms in animal models with spleen-qi deficiency[5][8]. The main active herbal ingredients are not fully detailed in the available sources, but the name suggests inclusion of Baizhu (Atractylodes macrocephala) and possibly Hibiscus leaves. Its primary indications are musculoskeletal inflammation (such as knee synovitis) and postpartum recovery related to TCM-defined spleen-qi deficiency.
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