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Xiezhuo Tongluo Fang

Development stage
Preclinical
Administration
Oral
01

Overview

Xiezhuo Tongluo Fang (泄浊通络方) is a traditional Chinese medicine (TCM) formula. The name translates to "Eliminating Turbidity and Unblocking the Collaterals Formula." It is not a single chemical entity but rather a multi-herbal prescription, typically used in TCM for conditions associated with internal dampness, turbidity, blood stasis, and obstruction of the meridians or collaterals. The formula's mechanism of action is based on TCM principles such as promoting diuresis to eliminate dampness/turbidity, activating blood circulation to resolve stasis, and unblocking channels to relieve symptoms like edema or pain. Its specific herbal composition may vary by practitioner or indication but often includes herbs with effects such as clearing heat and toxins (e.g., rhubarb/dahuang), promoting urination (e.g., plantago seed/cheqianzi), invigorating blood flow (e.g., safflower/honghua), resolving phlegm/dampness (e.g., poria/fu ling), among others[8]. It has been used in clinical practice for chronic kidney disease, chronic renal failure, hypertension with fluid retention, and other disorders characterized by "turbid toxin" accumulation according to TCM theory[8]. Modern research suggests some components may have anti-inflammatory, diuretic, immunomodulatory or nephroprotective effects.

Other names
泄浊通络方
02

Targets

VEGFA (Vascular endothelial growth factor A)IL-6 (Interleukin 6)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TNFA (Tumor necrosis factor alpha (soluble))

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