Drug intelligence / Profile preview

xijiao dihuang decoction + erzhi pill

Development stage
Preclinical
Lead developer
Peking University Third Hospital
Modality
Small Molecules
Administration
Oral
01

Overview

xijiao dihuang decoction + erzhi pill is a combination of two traditional Chinese medicine (TCM) formulas used primarily in China for the treatment of hematological disorders. Xijiao Dihuang Decoction (comprising Cornu Bubali, Rehmannia glutinosa, Paeonia suffruticosa, and Paeonia lactiflora) is traditionally indicated for clearing heat and cooling the blood, while Erzhi Pill (comprising Ligustrum lucidum and Eclipta prostrata) is used to nourish the liver and kidney yin. This specific combination has been investigated by the San Huan Cancer Hospital in Beijing for its efficacy in managing thrombocytopenia, particularly chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors and immune thrombocytopenic purpura (ITP). The therapeutic effect is attributed to its ability to modulate the immune system, reduce platelet destruction, and promote bone marrow recovery and megakaryocyte maturation.

Other names
Xijiao Dihuang Tang + Erzhi WanRhinoceros Horn and Rehmannia Decoction + Two-Ultimate PillXJDHD + EZP
02

Targets

IL1B (Interleukin-1 beta)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)EGFR T790M (Epidermal growth factor receptor T790M mutant)IL-6 (Interleukin 6)

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