Drug intelligence / Profile preview

Xilda-M

Development stage
Phase 4
Lead developer
Dios Lifesciences
Modality
Small Molecules
Administration
Oral
01

Overview

Xilda-M is a fixed-dose combination anti-diabetic medication developed and marketed by Dios Lifesciences. It contains two active ingredients: metformin, a biguanide, and vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor. Metformin works by reducing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. Vildagliptin functions by inhibiting the DPP-4 enzyme, which prevents the degradation of incretin hormones like glucagon-like peptide-1 (GLP-1), thereby stimulating insulin secretion and suppressing glucagon release in a glucose-dependent manner. This combination is indicated for the management of glycemic control in patients with type 2 diabetes mellitus, helping to reduce the risk of serious complications such as kidney damage, blindness, and cardiovascular events.

Brand names
Xilda-MXilda-M 500Xilda-M500Xilda-M-500Xilda-M 1000Xilda-M1000Xilda-M-1000
Other names
metformin + vildagliptin
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)DPP-4 (Dipeptidyl Peptidase-IV)ND1 (Mitochondrial electron transport chain complex I)

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