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xing qi dao zhi decoction
- Development stage
- Unknown
- Lead developer
- Yueyang Hospital of Integrated Traditional Chinese and Western Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Xingqi Daozhi Decoction is a Traditional Chinese Medicine (TCM) formula developed by Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, affiliated with the Shanghai University of Traditional Chinese Medicine, specifically for the treatment of functional constipation (Qi-stagnation type). The decoction is composed of several botanical ingredients, including *Magnolia officinalis*, *Citrus aurantium*, and *Aucklandia lappa*, which work synergistically to promote gastrointestinal motility and alleviate abdominal distension. Its mechanism of action involves the modulation of the enteric nervous system, specifically by increasing the expression of excitatory neurotransmitters like serotonin (5-HT) and substance P, while decreasing inhibitory factors such as vasoactive intestinal peptide (VIP). Clinical research indicates that the formula effectively improves bowel movement frequency and stool consistency, making it a significant therapeutic option in integrated medicine for chronic digestive disorders.
- Other names
- Xingqi Daozhi TangXingqi Daozhi Formula
02
Targets
TACR1 (Neurokinin‑1 Receptor)5-HT (Serotonin receptors)VPAC (VIP receptor family)
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