Drug intelligence / Profile preview

Xinglou Chengqi Decoction

Development stage
Phase 2
Administration
Oral
01

Overview

Xinglou Chengqi Decoction is a traditional Chinese medicine (TCM) formula composed of three botanical drugs and one inorganic drug. It was originally developed as "Huatan Tongfu" decoction in 1986 and later renamed to its current name for clinical use in the treatment of acute stroke, particularly ischemic stroke complicated with Tanre Fushi (TRFS) syndrome[5]. The decoction contains a complex mixture of chemical constituents—197 compounds have been identified or tentatively characterized—with 22 key active ingredients such as luteolin, apigenin, and chrysoeriol shown to exhibit anti-neuroinflammatory effects[5]. Mechanistically, these components are believed to act on multiple targets involved in inflammation and immune-related pathways. Preclinical studies indicate that Xinglou Chengqi Decoction can improve neurological function after experimental stroke by modulating the gut microbiota and regulating neuroinflammation[3][6]. Clinical network meta-analyses suggest it may be effective for improving outcomes in patients with ischemic stroke when compared to standard care or other TCM formulas[4].

Brand names
Xinglouchengqi granules
Other names
XLCQDXLCQ decoctionXinglou Chengqi Tang
02

Targets

Nuclear factor kappa-light-chain-enhancer of activated B cells pathway proteinsAKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)HSP90AA1 (Heat shock protein HSP90-alpha)

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