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Xingnao Jianshen prescription
- Development stage
- Unknown
- Lead developer
- Hospital Affiliated to Changchun University of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Xingnao Jianshen prescription is a Traditional Chinese Medicine (TCM) herbal compound developed by the Affiliated Hospital of Changchun University of Traditional Medicine for the treatment of acute ischemic stroke. It is specifically indicated for patients exhibiting the 'phlegm-heat fu-organ' pattern, a specific diagnostic category in TCM. The prescription is typically administered as an adjunct to standard Western medical therapy. Clinical evaluation focuses on improvements in neurological function (NIHSS), activities of daily living (Barthel Index), and overall disability (modified Rankin Scale). Preclinical research utilizes HPLC/MS-MS and transcriptomics in rat models of middle cerebral artery occlusion (MCAO) to investigate its multi-target pharmacodynamic mechanisms, which likely involve neuroprotection and modulation of the inflammatory response.
- Other names
- Xingnao Jianshen decoctionXingnao Jianshen formulaXingnao Jianshen Fang
02
Targets
AcetylcholinesteraseADRA1B (α1B)ADRB2 (β2)CASP3 (Caspase-3)M1 (Muscarinic acetylcholine receptor M1)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)PPARG (Peroxisome proliferator-activated receptor gamma)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)STAT3 (Signal Transducer and Activator of Transcription 3)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)
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