Drug intelligence / Profile preview

Xingnaojing injection

Development stage
Unknown
Lead developer
Henan Tiandi Pharmaceutical
Administration
Intravenous
01

Overview

Xingnaojing injection (XNJ) is an approved traditional Chinese medicine (TCM) injection derived from the classical Angong Niuhuang pill formulation. It is composed of four primary active herbal ingredients: Moschus (musk), Borneolum syntheticum (synthetic borneol), Curcuma aromatica (radix curcumae), and Gardenia jasminoides (fructus gardenia). Xingnaojing is approved by the National Medical Products Administration (NMPA) of China as a neuroprotective agent and is indicated for the treatment of apoplectic coma, hemiplegia, acute ischemic stroke, and intracerebral hemorrhage. Its pharmacological mechanisms include scavenging free radicals, reducing cerebral edema and hypoxia, increasing brain cell metabolic activity, and modulating the PI3K/Akt/eNOS and SIRT1 signaling pathways to confer neuroprotection and anti-inflammatory effects.

Other names
XNJXNJIXingnaojingXingnaojing Zhusheye醒脑静注射液
02

Targets

PGK1 (3-phosphoglycerate kinase 1)NOS3 (eNOS)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)AKT (RAC-alpha serine/threonine-protein kinase)

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