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Xingpi Jieyu Fang
- Development stage
- Phase 4
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Xingpi Jieyu Fang (醒脾解郁方) is a traditional Chinese medicine (TCM) herbal formula. It is used in TCM practice for the treatment of conditions associated with spleen deficiency and stagnation of liver qi, which may manifest as symptoms such as depression, fatigue, poor appetite, and digestive disturbances. The formula typically consists of multiple herbs combined according to TCM principles to synergistically "awaken the spleen" and "relieve constraint/depression." Like other classic TCM formulas, it is designed based on a hierarchical structure where each herb plays a specific role (monarch, minister, assistant, envoy)[4]. The mechanism of action involves multi-target modulation—regulating gastrointestinal function and mood through effects on neurotransmitters and gut-brain axis pathways. However, its precise pharmacological mechanisms are not fully elucidated in modern biomedical terms.
- Brand names
- Xingpi Jieyu Fang
- Other names
- 醒脾解郁方
02
Targets
NOS3 (eNOS)VEGFA (Vascular endothelial growth factor A)GR (Glucocorticoid receptor)JNK (Mitogen-activated protein kinase kinase kinase family)HIF1A (Hypoxia-inducible factor 1-alpha)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ESR1 (ERα)IL-6 (Interleukin 6)FOS (Activator Protein 1)
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