Drug intelligence / Profile preview

Xiongdan Powder

Development stage
Unknown
Lead developer
Chengdu Yongkon Pharmacy
Administration
Oral, Topical
01

Overview

Xiongdan Powder (Bear Bile Powder) is a traditional Chinese medicine derived from the dried bile of the black bear (*Ursus thibetanus*) or brown bear (*Ursus arctos*). It is approved in China for the treatment of heat-related convulsions, red swollen eyes, and sore throat. The primary active components of Xiongdan Powder are bile acids, specifically tauroursodeoxycholic acid (TUDCA), ursodeoxycholic acid (UDCA), and chenodeoxycholic acid (CDCA). These active ingredients act as agonists of the G-protein coupled bile acid receptor 1 (GPBAR1/TGR5) and the farnesoid X receptor (FXR), which regulate bile acid homeostasis, lipid metabolism, and inflammatory pathways. Chengdu Yongkon Pharmacy is a key developer and manufacturer of this product.

Brand names
DimujiaXiong Zhi Yuan
Other names
Bear Bile PowderBear Gall Powderxiongdan fen熊胆粉熊胆粉1熊胆粉2
02

Targets

ABCB11 (Bile salt export pump)CYP7A1 (Cholesterol 7alpha-hydroxylase)FXR (Farnesoid x-activated receptor)GPBAR1NR0B2 (Small heterodimer partner)

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