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Xiongzhi Dilong Decoction

Development stage: Preclinical
Administration: Oral

Overview

Xiongzhi Dilong Decoction (XZDLD) is a traditional Chinese medicine formula derived from the classical prescription "Xiongzhi Shigao decoction" in Yi-zong-jin-jian. It is primarily used for the treatment of migraine and has demonstrated efficacy in experimental models of chronic migraine. Mechanistically, XZDLD exerts anti-migraine effects by modulating tryptophan and tyrosine metabolic pathways, reducing plasma levels of calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase activating polypeptide (PACAP), inhibiting inducible nitric oxide synthase (iNOS) expression, and suppressing phosphorylation of p38 MAPK. These actions collectively increase pain threshold and reduce neurogenic inflammation associated with migraine[1][2][3].

Other names: Xiongzhi Dilong decoctionXZDLD熊芷地龙汤

Targets

NOS2 (Nitric Oxide Synthase 2)ADCYAP1R1 (Pituitary adenylate cyclase-activating polypeptide receptor PAC1)

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