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Xiongzhi Tongluo formula

Development stage: Unknown
Lead developer: Xiyuan Hospital
Administration: Oral

Overview

Xiongzhi Tongluo formula is a Traditional Chinese Medicine (TCM) herbal preparation developed by Xiyuan Hospital of the China Academy of Chinese Medical Sciences. It is primarily investigated for the treatment of ischemic stroke, utilizing the TCM therapeutic principle of 'unblocking the collaterals' (Tongluo) to promote blood circulation and neurological recovery. The formula typically incorporates botanical components such as *Ligusticum chuanxiong* (Chuanxiong) and *Angelica dahurica* (Baizhi), which are traditionally used to treat vascular and pain-related conditions. It is currently being evaluated in exploratory clinical trials to assess its efficacy and safety in patients recovering from ischemic stroke.

Brand names: Xiongzhi Tongluo Formula
Other names: Xiongzhi Tongluo Fang

Targets

MMP2 (Matrix metalloproteinase-2)BCL2L1 (B-cell lymphoma-extra large protein)STAT1 (Signal transducer and activator of transcription protein 1)CDKN2A (Cyclin-dependent kinase inhibitor 2A)NFKB1 (NF-κB1)RAF1 (c-Raf-1 (Y340D/Y341D))IL-6 (Interleukin 6)

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